Eukaryotic High Mobility Group Protein 1 (HMGB1)

HMG1; HMG3; SBP1; Sulfoglucuronyl Carbohydrate Binding Protein; Amphoterin; High Mobility Group Box 1 Protein

  • 高迁移率族蛋白1(HMGB1)真核蛋白 产品包装(模拟)
  • 高迁移率族蛋白1(HMGB1)真核蛋白 产品包装(模拟)
  • 高迁移率族蛋白1(HMGB1)真核蛋白 Figure. Gene Sequencing (Extract)
  • EPA399Hu62.jpg Figure. SDS-PAGE
  • Certificate 通过ISO 9001、ISO 13485质量体系认证



Reconstitute in 10mM PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex.






编号 适用物种:Homo sapiens (Human,人) 应用(仅供研究使用,不用于临床诊断!)
APA399Hu02 高迁移率族蛋白1(HMGB1)活性蛋白 Cell?culture;?Activity?Assays.
EPA399Hu62 高迁移率族蛋白1(HMGB1)真核蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
EPA399Hu63 高迁移率族蛋白1(HMGB1)真核蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
EPA399Hu61 高迁移率族蛋白1(HMGB1)真核蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
RPA399Hu02 高迁移率族蛋白1(HMGB1)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
APA399Hu61 高迁移率族蛋白1(HMGB1)活性蛋白 Cell?culture;?Activity?Assays.
RPA399Hu01 高迁移率族蛋白1(HMGB1)重组蛋白 Positive Control; Immunogen; SDS-PAGE; WB.
PAA399Hu06 高迁移率族蛋白1(HMGB1)多克隆抗体 WB; IHC; ICC; IP.
PAA399Hu01 高迁移率族蛋白1(HMGB1)多克隆抗体 WB; IHC; ICC; IP.
PAA399Hu02 高迁移率族蛋白1(HMGB1)多克隆抗体 WB; IHC; ICC; IP.
LAA399Hu71 高迁移率族蛋白1(HMGB1)多克隆抗体(生物素标记) WB; IHC; ICC.
LAA399Hu81 高迁移率族蛋白1(HMGB1)多克隆抗体(异硫氰酸荧光素标记) WB; IHC; ICC; IF.
MAA399Hu22 高迁移率族蛋白1(HMGB1)单克隆抗体 WB; IHC; ICC; IP.
MAA399Hu21 高迁移率族蛋白1(HMGB1)单克隆抗体 WB; IHC; ICC; IP.
SEA399Hu 高迁移率族蛋白1(HMGB1)检测试剂盒(酶联免疫吸附试验法) Enzyme-linked immunosorbent assay for Antigen Detection.
IEA399Hu 高迁移率族蛋白1(HMGB1)检测试剂盒(酶联免疫吸附试验法,快捷型) Enzyme-linked immunosorbent assay for Antigen Detection.
SCA399Hu 高迁移率族蛋白1(HMGB1)检测试剂盒(化学发光免疫分析法) Chemiluminescent immunoassay for Antigen Detection.
KSA399Hu01 高迁移率族蛋白1(HMGB1)检测试剂盒DIY材料(酶联免疫吸附试验法) 自己动手制作ELISA试剂盒的主要材料
PGA399Hu01 高迁移率族蛋白1(HMGB1)引物对 PCR


杂志 参考文献
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine High mobility group box protein-1 (HMGB-1) as a new diagnostic marker in patients with acute appendicitis [PubMed: PMC3094252]
Respiration Protective Effect of Nicotine on Lipopolysaccharide-Induced Acute Lung Injury in Mice [Karger: 000319151]
Surgery Clinical relevance of single nucleotide polymorphisms of the high mobility group box 1 protein gene in patients with major trauma in Southwest China [Pubmed: 22047946]
Viral Immunology Is HMGB1 a New Indirect Marker for Revealing Fibrosis in Chronic Hepatitis and a New Therapeutic Target in Treatment? [Wiley: source]
Chinese Medical Journal Severity of sepsis is correlated with the elevation of serum high-mobility group box 1 in rats [CMJ: 2009218808935901080]
Microbiology and Immunology Diagnostic value of serum concentrations of high-mobility group-box protein 1 and soluble hemoglobin scavenger receptor in brucellosis [PubMed: 23278480]
ACTA biochimica polonica High mobility group B1 levels in sepsis and disseminated intravascular coagulation [Actabp: Source]
Anesthesia and Analgesia The Inhibitory Effect of Lidocaine on the Release of High Mobility Group Box 1 in Lipopolysaccharide-Stimulated Macrophages [PubMed: 21288974]
Rheumatology International Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life [PubMed: 23143556]
Inflammation Research Mammalian target of rapamycin complex 2 regulates inflammatory response to stress [PubMed: 22899279]
Acta Biochimica et Biophysica Sinica IGF-1 alleviates ox-LDL-induced inflammation via reducing HMGB1 release in HAECs [PubMed: 22782142]
LabVest The suppression of TRIM21 and the accumulation of IFN-α play crucial roles in the pathogenesis of osteonecrosis of the femoral head. [PubMed: 22825687]
Biomark Insights Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism [PubMed: PMC3623607]
Evidence-based Complementary and Alternative Medicine ATF3 Protects against LPS-Induced Inflammation in Mice via Inhibiting HMGB1 Expression [PubMed: PMC3770047]
Exp Ther Med Correlation between serum high-mobility group box-1 levels and high-sensitivity C-reactive protein and troponin I in patients with coronary artery disease [Pubmed: 23935732]
International of Rheumatic disesases Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia [Pubmed: 23901875]
Surgery A novel serum marker for biliary tract cancer: Diagnostic and prognostic values of quantitative evaluation of serum mucin 5AC (MUC5AC) [Pubmed: 24468034]
Acta Pharmacol Sin. Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE-/- mice by downregulating the HMGB1-RAGE axis [Pubmed: 23564080]
BMC pulmonary medicine Soluble receptor for advanced glycation end-products and progression of airway disease [Pubmed: 24758342]
Biochemical Pharmacology Ascorbic acid reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and improves survival rate in septic mice by activation of Nrf2/HO-1 signals [Pubmed:25896849]
BioMed Research International Effects of Single or Combined Treatments with Radiation and Chemotherapy on Survival and Danger Signals Expression in Glioblastoma Cell Lines [Hindawi:Source]
J Cardiothorac Surg. High plasma levels of high mobility group box 1 is associated with the risk of sepsis in severe blunt chest trauma patients: a prospective cohort study [Pubmed:Pmc4132233]
J Leukoc Biol. HMGB1 is an early and critical mediator in an animal model of uveitis induced by IRBP-specific T cells [Pubmed:24374967]
PLOS ONE The Alarmin Concept Applied to Human Renal Transplantation: Evidence for a Differential Implication of HMGB1 and IL-33 [Pubmed:24586382]
Journal of Surgical Research Plasma levels of high mobility group box 1 increase in patients with posttraumatic stress disorder after severe blunt chest trauma: a prospective cohort study [Pubmed:25016440]
Virus Research High-mobility group box-1, promising serological biomarker for the distinction of human WNV disease severity [Pubmed:25197038]
Journal of Stroke and Cerebrovascular Diseases Increased VEGF and Decreased SDF-1α in Patients with Silent Brain Infarction Are Associated with Better Prognosis after First-Ever Acute Lacunar Stroke [Pubmed:25601176]
中华临床医师杂志 高迁移率族蛋白B1和神经元烯醇化酶对心脏骤停大鼠复苏后脑损伤评价的研究 [Journal: Fulltext]
Oxidative Medicine and Cellular Longevity Diabetes-Induced Oxidative Stress in Endothelial Progenitor Cells May Be Sustained by a Positive Feedback Loop Involving High Mobility Group Box-1 [Journals: Omcl]
Int Immunopharmacol Hesperidin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting HMGB1 release [PubMed: 25724384]
Journal of Immunotherapy Wogonin Inhibits Tumor-derived Regulatory Molecules by Suppressing STAT3 Signaling to Promote Tumor Immunity [PubMed: 25962106]
Atherosclerosis Retinoic acid inhibits tissue factor and HMGB1 via modulation of AMPK activity in TNF-α activated endothelial cells and LPS-injected mice [PubMed: 26116962]
PLOS ONE Plasma HMGB-1 Levels in Subjects with Obesity and Type 2 Diabetes: A Cross-Sectional Study in China [PubMed: 26317615]
Int Immunopharmacol Betulin attenuates lung and liver injuries in sepsis [PubMed: 26644168]
journal of cardiochoracic surgery High mobility group box 1 gene polymorphism is associated with the risk of postoperative atrial fibrillation after coronary artery bypass surgery [PubMed: 26109393]
Int Immunopharmacol Glycyrrhizin reduces HMGB1 secretion in lipopolysaccharide-activated RAW 264.7 cells and endotoxemic mice by p38/Nrf2-dependent induction of HO-1 [PubMed: 25812767]
World J Gastroenterol Overexpression of HMGB1 A-box reduced lipopolysaccharide-induced intestinal inflammation via HMGB1/TLR4 signaling in vitro [PubMed: 26167076]
Neurotoxicology Allopurinol reduces severity of delayed neurologic sequelae in experimental carbon monoxide toxicity in rats [PubMed: 25845300]
Journal of Neuroimmunology HMGB1 expression patterns during the progression of experimental autoimmune encephalomyelitis [PubMed: 25773152]
J Neuroinflammation HMGB1 release triggered by the interaction of live retinal cells and uveitogenic T cells is Fas/FasL activation-dependent [PubMed: 26394985]
PLoS One Low Shear Stress Induced HMGB1 Translocation and Release via PECAM-1/PARP-1 Pathway to Induce Inflammation Response [PubMed: 25793984]
Neuroscience Interleukin-33 is released in spinal cord and suppresses experimental autoimmune encephalomyelitis in mice [PubMed: 26363151]
Cancer Biomarkers Serum levels of HMGB1 have a diagnostic role in metastatic renal cell cancer [Pubmed:27062570]
International Immunopharmacology Oxymatrine attenuates CCl 4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways [Pubmed:27179304]
SpringerPlus Ethyl pyruvate?attenuated?coxsackievirus?B3-induced?acute?viral?myocarditis?by?suppression?ofHMGB1/RAGE/NF-ΚB?pathway. [Pubmed:27026909]
Acta Biochim Biophys Sin (Shanghai). High mobility group box1 protein is involved in acute?inflammation?induced by Clostridium difficile toxin A. [content:2016]
United States Patent Application METHOD OF MAKING A SKIN CARE COMPOSITION [y2016:0077080.html]
Oxid Med Cell Longev. Oxidative Stress in Metabolic Disorders: Pathogenesis, Prevention, and Therapeutics [Pubmed:26949450]
Oncotarget Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors [pubmed:26980746]
clinical biochemistry Relevance of pre-analytical blood management on the emerging cardiovascular protein biomarkers TWEAK and HMGB1 and on miRNA serum and plasma profiling. [pubmed:27847340]
disease markers Serum HMGB1 as a Potential Biomarker for Patients with Asbestos-Related Diseases. [pubmed:28348451]
Biogerontology. Changes in pro-inflammatory markers and leucine concentrations in response to Nordic Walking training combined with vitamin D supplementation in elderly women. [pubmed:28316011]
Journal of Immunology Research Serum HMGB1 serves as a novel laboratory indicator reflecting disease activity and [pubmed:27800496]
Springerplus Ethyl pyruvate attenuated coxsackievirus B3-induced acute viral myocarditis by suppression of HMGB1/RAGE/NF-ΚB pathway [pubmed:27026909]
Molecular?Immunology HMGB1 blockade differentially impacts pulmonary inflammation and defense responses in poly (I: C)/LPS-exposed heart transplant mice [pubmed:27387278]
Oxidative Medicine and Cellular Longevity Reduced HMGB 1-Mediated Pathway and Oxidative Stress in Resveratrol-Treated Diabetic Mice: A Possible Mechanism of Cardioprotection of Resveratrol in … [pubmed:27833703]
BioMed?Research?International? High Mobility Group Box1 Protein Is Involved in Endoplasmic Reticulum Stress Induced by Clostridium difficile Toxin A [pubmed:27579314]
Cardiology The role of high mobility group box 1 protein in interleukin-18-induced myofibroblastic transition of valvular interstitial cells [pubmed:27395056]
Innate?immunity HMGB1 exacerbates experimental mouse colitis by enhancing innate lymphoid cells 3 inflammatory responses via promoted IL-23 production [pubmed:27670944]
Urolithiasis. Urinary?MCP-1、HMGB1?increased?in?calcium?nephrolithiasis?patients?and the?influence?ofhypercalciuria?on the?production?of the?two?cytokines. [pubmed:27393275]
Journal?of?Investigative?Surgery Diagnostic?Value?of?High-Mobility Group Box 1?(HMGB1)?Protein?in?Acute?and?Perforated Appendicitis. [pubmed:27922766]
J Cell Biochem High Mobility Group Box 1 Mediates Interferon-r-Induced Phenotypic Modulation of Vascular Smooth Muscle Cells. [pubmed:27579780]
BMC Vet Res. Blood markers of fibrinolysis and endothelial activation in canine babesiosis. [pubmed:28363279]
Immunol Res. Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells. [pubmed:28108937]
Biomed Pharmacother. SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death. [pubmed:28122311]
Sci Rep.? Bone marrow-derived mesenchymal stem cells (BMSCs) repair acute necrotized pancreatitis by secreting microRNA-9 to target the NF-κB1/p50 gene in rats. [pubmed:28373667]
Integrative Cancer Science and Therapeutics The expression of HMGB1 and the receptor for advanced glycation end products (RAGE) in epithelial ovarian cancer [pdf:ICST-4-232.pdf]
Journal of Food and Drug Analysis Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of?Cinnamomum osmophloeum?Kanehira in endotoxin-induced … [S1021-9498(17)30081-9]
Biomedicine & Pharmacotherapy SIRT1 inhibits releases of HMGB1 and HSP70 from human umbilical vein endothelial cells caused by IL-6 and the serum from a preeclampsia patient and protects the cells from death [DOI:10.1016/j.biopha.2017.01.087]
Stem Cell Rev and Rep Induction of?Immunogenic Cell Death in?Lymphoma Cells by?Wharton’s Jelly Mesenchymal Stem Cell Conditioned Medium [pubmed:28918474]
Scientific Reports COMMUNICATIONS Mineral particles stimulate innate immunity through neutrophil extracellular traps containing HMGB1 [pubmed:29192209]
Biochemical and Biophysical Research Communications Oxidized low-density lipoprotein promotes osteoclast differentiation from CD68 positive mononuclear cells by regulating HMGB1 release [pubmed:29146189]
Pulmonary Pharmacology & Therapeutics HMGB1 promotes HLF-1 proliferation and ECM production through activating HIF1-a-regulated aerobic glycolysis [pubmed:28571757]
Biomedical Research Correlation between high mobility group box 1 protein, tumor necrosis factor-α, and acute coronary syndrome [ISSN 0970-938X]
Molecular Cancer PERK induces resistance to cell death elicited by endoplasmic reticulum stress and chemotherapy [pubmed:28499449]
BMC Complementary and Alternative Medicine Assessing the recovery from prerenal and renal acute kidney injury after treatment with single herbal medicine via activity of the biomarkers HMGB1, NGAL and KIM-1 in kidney proximal tubular cells treated by cisplatin with different doses and exposure times. [pubmed:29258482]
25 Blocking the Feedback Loop between Neuroendocrine Differentiation and Macrophages Improves the Therapeutic Effects of Enzalutamide (MDV3100) on Prostate Cancer. [pubmed:29191973]
Nature microbiology Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection. [pubmed:27748732]
Cellular physiology and biochemistry Macrophage Inflammatory Protein-2 in High Mobility Group Box 1 Secretion of Macrophage Cells Exposed to Lipopolysaccharide. [pubmed:28662496]
Molecular Medicine Reports Niclosamide attenuates inflammatory cytokines via the autophagy pathway leading to improved outcomes in renal ischemia/reperfusion injury [pubmed:28627643]
Cell?Death?&?Disease AMP-activated protein kinase agonist N 6-(3-hydroxyphenyl) adenosine protects against fulminant hepatitis by suppressing inflammation and apoptosis [Articles:s41419-017-0118-0]
Journal of Molecular?Cell?Biology S1 PR 3 is essential for phosphorylated fingolimod to protect astrocytes against oxygen‐glucose deprivation‐induced neuroinflammation via inhibiting TLR 2/4‐NF κB?… [Pubmed:29536648]
Frontiers in Immunology Glycyrrhizin Protects Mice against Experimental Autoimmune Encephalomyelitis by Inhibiting HMGB1 Expression and Neuronal HMGB1 Release [Pubmed:30013568]
Oncoimmunology Bromodomain inhibition exerts its therapeutic potential in malignant pleural mesothelioma by promoting immunogenic cell death and changing the tumor immune?… [Pubmed:29399399]
Cancer Immunology, Immunotherapy Tumor lysate-based vaccines: on the road to immunotherapy for gallbladder cancer [Pubmed:29600445]
Cytokine Porcine reproductive and respiratory syndrome virus induces concurrent elevation of High Mobility Group Box-1 protein and pro-inflammatory cytokines in?… [Pubmed:29895396]
Frontiers in Neurology Ursolic Acid Ameliorates Inflammation in Cerebral Ischemia and Reperfusion Injury Possibly via High Mobility Group Box 1/Toll-Like Receptor 4/NFκB?… [Pubmed:29867706]
Biomedicine & Pharmacotherapy Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death [Pubmed:29958141]
Inflammation?Research Luteolin activates ERK1/2- and Ca-dependent HO-1 induction that reduces LPS-induced HMGB1, iNOS/NO, and COX-2 expression in RAW264.7 cells and?… [Pubmed:29497773]
Journal of?Food?and?Drug?Analysis Anti-inflammatory effect of cinnamaldehyde and linalool from the leaf essential oil of Cinnamomum osmophloeum Kanehira in endotoxin-induced mice [Pubmed:29389558]
Biochemical and Biophysical?Research?Communications Sirt1 S-nitrosylation induces acetylation of HMGB1 in LPS-activated RAW264. 7 cells and endotoxemic mice [Pubmed:29680657]
Neurological Sciences Thrombomodulin, alarmin signaling, and copeptin: cross-talk between obesity and acute ischemic stroke initiation and severity in Egyptians [Pubmed:29637447]
International Journal of Gynecology & Obstetrics Increased serum levels of high mobility group protein B1 and calprotectin in pre‐eclampsia [Pubmed:29569400]
Advances in Experimental?Medicine?and?Biology Molecules of Damage-Associated Patterns in Bronchoalveolar Lavage Fluid and Serum in Chronic Obstructive Pulmonary Disease [Pubmed:29429028]
Taiwanese Journal of Obstetrics & Gynecology HMGB1-RAGE signaling pathway in pPROM [Pubmed:29673663]
Chronic obstructive pulmonary disease (COPD)--from biomarkers to clinical phenotypes [ISBN:978-951-51-4039-5]
Journal?of?Pharmacological?Sciences Butyrate suppresses abnormal proliferation in colonic epithelial cells under diabetic state by targeting HMGB1 [Doi: 10.1016/j.jphs.2018.07.012]
Biomaterials Science Delivery of 5'-Triphosphate RNA with Endosomolytic Nanoparticles Potently Activates RIG-I to Improve Cancer Immunotherapy [Doi: 10.1039/C8BM01064A?]
iris-AperTO []
Toxicological Sciences Apoptosis resistance in fibroblasts precedes progressive scarring in pulmonary fibrosis and is partially mediated by Toll-like receptor 4 activation [Pubmed: 31020321]
Molecular Medicine FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic?… [Pubmed: 31215394]
international immunopharmacology Dulaglutide mitigates inflammatory response in fibroblast-like synoviocytes [Pubmed: 31185450]
Food & Function Network pharmacology oriented study reveals inflammatory state-dependent dietary supplement hepatotoxicity responses in normal and diseased rats [Pubmed: 31140472]
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